Chemical Structure : GSK-1059865
CAS No.:
1191044-58-2
GSK-1059865
(GSK 1059865, GSK1059865)
Catalog No. : PC-60752Not For Human Use, Lab Use Only.
GSK-1059865 is a highly potent, selective orexin-1 receptor (OX1R) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6075201
Biological Activity
GSK-1059865 is a highly potent, selective orexin-1 receptor (OX1R ) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively.
Physicochemical Properties
M.Wt
436.325
Formula
C20H23BrFN3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-bromo-N-({1-[(3-fluoro-2-methoxyphenyl)carbonyl]-5-methylpiperidin-2-yl}methyl)pyridin-2-amine
References
1. Gozzi A, et al. PLoS One. 2011 Jan 28;6(1):e16406.
2. Gozzi A, et al. Neuropsychopharmacology. 2013 Oct;38(11):2120-30.
3. Aluisio L, et al. Front Neurosci. 2014 May 20;8:107.
4. Bonaventure P, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):590-601.
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