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Chemical Structure : GSK-1059865
Catalog No.: PC-60752Not For Human Use, Lab Use Only.
A highly potent, selective orexin-1 receptor (OX1R) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively.
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A highly potent, selective orexin-1 receptor (OX1R) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively; displays >80-fold selectivity over OX2R; robustly inhibits the response in fronto-hippocampal regions in rats, significantly decreases ethanol drinking in a dose-dependent manner in CIE-exposed mice.
| M.Wt | 436.325 | |
| Formula | C20H23BrFN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gozzi A, et al. PLoS One. 2011 Jan 28;6(1):e16406.
2. Gozzi A, et al. Neuropsychopharmacology. 2013 Oct;38(11):2120-30.
3. Aluisio L, et al. Front Neurosci. 2014 May 20;8:107.
4. Bonaventure P, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):590-601.
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