Chemical Structure : MK-1064
CAS No.:
1207253-08-4
MK-1064
(MK1064;MK 1064)
Catalog No. : PC-45747Not For Human Use, Lab Use Only.
MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4574701
Biological Activity
MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R ) antagonist with Ki/IC50 of 0.5/18 nM.
Physicochemical Properties
M.Wt
461.9003
Formula
C24H20ClN5O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
[2,2':5',3''-Terpyridine]-3'-carboxamide, 5''-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-
References
1. Roecker AJ, et al. ChemMedChem. 2014 Feb;9(2):311-22.
2. Gotter AL, et al. Sci Rep. 2016 Jun 3;6:27147.
3. Grafe LA, et al. Neuroscience. 2017 Apr 21;348:313-323.
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