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SB-408124 hydrochloride

Chemical Structure : SB-408124 hydrochloride

CAS No.: 1431697-90-3

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SB-408124 hydrochloride (SB 408124 Hydrochloride;SB408124 Hydrochloride)

Catalog No.: PC-45972Not For Human Use, Lab Use Only.

A potent, selective OX1 receptor antagonist with Ki of 57 nM (whole cell assay), and 27 nM (cell membrane-based SPA assay).

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50 mg $224 In stock
100 mg $400 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, selective OX1 receptor antagonist with Ki of 57 nM (whole cell assay), and 27 nM (cell membrane-based SPA assay); displays 50-fold selectivity over OX2 receptor; prevents the stimulatory effect of Olanzapine on endogenous glucose production.

Physicochemical Properties

M.Wt 392.8302
Formula C19H19ClF2N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-, hydrochloride (1:1)

References

1. Langmead CJ, et al. Br J Pharmacol. 2004 Jan;141(2):340-6.

2. Malherbe P, et al. Mol Pharmacol. 2009 Sep;76(3):618-31.

3. Girault EM, et al. Brain Res. 2013 Aug 21;1527:238-45.

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