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SB-674042

Chemical Structure : SB-674042

CAS No.: 483313-22-0

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SB-674042 (SB 674042, SB674042)

Catalog No.: PC-42732Not For Human Use, Lab Use Only.

SB-674042 is a potent, selective nonpeptide Orexin 1 receptor (OX1R) antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-674042 is a potent, selective nonpeptide Orexin 1 receptor (OX1R) antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay.
SB-674042 displays 50-fold selectivity over OX2.
[3H]-SB-674042 is a specific, high-affinity radioligand for the OX1 receptor.

Physicochemical Properties

M.Wt 448.5125
Formula C24H21FN4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-

References

1. Langmead CJ, et al. Br J Pharmacol. 2004 Jan;141(2):340-6.

2. Malherbe P, et al. Mol Pharmacol. 2010 Jul;78(1):81-93.

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