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Chemical Structure : SB-674042
CAS No.: 483313-22-0
Catalog No.: PC-42732Not For Human Use, Lab Use Only.
A potent, selective nonpeptide Orexin 1 receptor antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $132 | In stock |
Bulk size, bulk discount!
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A potent, selective nonpeptide Orexin 1 receptor antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay; displays 50-fold selectivity over OX2; [3H]-SB-674042 is a specific, high-affinity radioligand for the OX1 receptor.
| M.Wt | 448.5125 | |
| Formula | C24H21FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]- |
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1. Langmead CJ, et al. Br J Pharmacol. 2004 Jan;141(2):340-6.
2. Malherbe P, et al. Mol Pharmacol. 2010 Jul;78(1):81-93.
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