ROXA-47 | Orexin receptor agonist | Probechem Biochemicals

Chemical Structure : ROXA-47

ROXA-47 (ROXA47)

Catalog No.: PC-27456Not For Human Use, Lab Use Only.

ROXA-47 is a potent, selective dual orexin receptor agonist with EC50 of 16 nM and 21 nM at OX1R and OX2R, respectively.

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Biological Activity

ROXA-47 is a potent, selective dual orexin receptor agonist with EC50 of 16 nM and 21 nM at OX1R and OX2R, respectively.
ROXA-47 enhances cognition in middle-aged mice.
ROXA-47 improves cognitive function in mice primarily via orexin receptor-1 (OX1R) activation.

Physicochemical Properties

M.Wt	664.78
Formula	C36H36N6O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-methoxy-N-methyl-3'-(N-(5-((2-(3-methylbenzamido)ethyl)amino)pyridin-3-yl)sulfamoyl)-N-(pyridin-4-ylmethyl)-[1,1'-biphenyl]-3-carboxamide

References

1. Mavanji V, et al. Pharmacol Biochem Behav. 2026 Jul 30:174246.

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ROXA-47 (ROXA47)

Biological Activity

Physicochemical Properties

References

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