Chemical Structure : (S)-(-)-DQP-997-74
CAS No.:
2377187-09-0
(S)-(-)-DQP-997-74
Catalog No.: PC-21030Not For Human Use, Lab Use Only.
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.
(S)-(-)-DQP-997-74 shows no activity at AMPA, GABA, glycine, nicotinic, or purinergic P2X receptors at 1 uM.
(S)-(-)-DQP-997-74 shows a time-dependent enhancement of inhibitory actions at GluN2C- and GluN2D-containing NMDARs in the presence of the agonist glutamate.
(S)-(-)-DQP-997-74 significantly reduced the number of epileptic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy.
Physicochemical Properties
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M.Wt
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570.37
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Formula
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C28H19Cl2F2N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-4-(5-(4-chlorophenyl)-3-(4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-3,3-difluoro-4-oxobutanoic acid
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References
1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.
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