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Chemical Structure : (S)-(-)-DQP-997-74
Catalog No.: PC-21030Not For Human Use, Lab Use Only.
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.
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(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.
(S)-(-)-DQP-997-74 shows no activity at AMPA, GABA, glycine, nicotinic, or purinergic P2X receptors at 1 uM.
(S)-(-)-DQP-997-74 shows a time-dependent enhancement of inhibitory actions at GluN2C- and GluN2D-containing NMDARs in the presence of the agonist glutamate.
(S)-(-)-DQP-997-74 significantly reduced the number of epileptic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy.
| M.Wt | 570.37 | |
| Formula | C28H19Cl2F2N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.
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