Chemical Structure : (S)-3,4-DCPG
CAS No.:
201730-11-2
(S)-3,4-DCPG
(S-3,4-DCPG, (S)-3,4-Dicarboxyphenylglycine)
Catalog No.: PC-22229Not For Human Use, Lab Use Only.
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
(S)-3,4-DCPG depressed the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) giving a biphasic concentration-response curve showing EC50 of 1.3 uM.
(S)-3,4-DCPG activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
(S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus in mice.
Physicochemical Properties
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M.Wt
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239.18
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Formula
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C10H9NO6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-4-(Amino(carboxy)methyl)phthalic acid
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References
1. Thomas NK, et al. Neuropharmacology. 2001 Mar;40(3):311-8.
2. Linden AM,et al. Neuropharmacology. 2003 Sep;45(4):473-83.
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