Catalog No.: PC-22229Not For Human Use, Lab Use Only.
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
(S)-3,4-DCPG depressed the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) giving a biphasic concentration-response curve showing EC50 of 1.3 uM.
(S)-3,4-DCPG activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
(S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus in mice.
Physicochemical Properties
M.Wt
239.18
Formula
C10H9NO6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-4-(Amino(carboxy)methyl)phthalic acid
References
1. Thomas NK, et al. Neuropharmacology. 2001 Mar;40(3):311-8.
