| Cat. No. |
Product Name |
Information |
| PC-27118 |
VU6066098
mGlu2 NAM
|
VU6066098 is a potent, selective, and CNS-penetrant mGlu2 negative allosteric modulator (NAM) with IC50 of 77 nM in mGlu2/GIRK assays, with no effect on mGlu3 (IC50>10 uM). |
| PC-26985 |
VU6053371
mGlu3 PAM
|
VU6053371/BI03738809 is a potent, selective, and centrally active metabotropic glutamate receptor subtype 3 (mGlu3) positive allosteric modulator (PAM) with EC50 of 103 nM and 112 nM for human and rat mGlu3. |
| PC-22900 |
VU6023326
mGlu2/mGlu3 PAM
|
VU6023326 (VU326) is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells. |
| PC-22271 |
MMPIP hydrochloride
mGluR7 antagonist
|
MMPIP hydrochloride is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM. |
| PC-22232 |
AZ12216052
mGluR8 PAM
|
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays. |
| PC-21049 |
MK-8768
mGluR2 NAM
|
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8. |
| PC-20615 |
ADX71743
mGluR7 NAM
|
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively. |
| PC-20614 |
CVN636
mGluR7 agonist
|
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively. |
| PC-20314 |
JNJ-42491293
mGlu2 ago-PAM
|
JNJ-42491293 (JNJ 42491293) is a potent, mGlu2-selective allosteric agonist and positive allosteric modulator (ago-PAM). |
| PC-49747 |
Mavoglurant
mGlu5 NAM
|
AFQ056 (Mavoglurant, AFQ-056) is a potent, subtype-selective and non-competitive inhibitor of mGluR5 with IC50 of 30 nM. |
| PC-49746 |
HTL14242
mGlu5 NAM
|
HTL14242 (HTL0014242) a potent, selective mGlu5 negative allosteric modulator (NAM) with pKi of 9.3 and pIC50 of 9.2, shows high selectivity within the metabotropic family of GPCRs. |
| PC-49593 |
VU6027459
mGlu7 PAM
|
VU6027459 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7). |
