| Cat. No. |
Product Name |
Information |
| PC-22232 |
AZ12216052
mGluR8 PAM
|
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays. |
| PC-49747 |
Mavoglurant
mGlu5 NAM
|
AFQ056 (Mavoglurant, AFQ-056) is a potent, subtype-selective and non-competitive inhibitor of mGluR5 with IC50 of 30 nM. |
| PC-49586 |
VU6046980
mGlu7 PAM
|
VU6046980 is a potent, selective and in vivo active mGlu7 positive allosteric modulator (PAM) with EC50 of 0.15 uM (rat mGlu7). |
| PC-49074 |
VU0360172
mGlu5 PAM
|
VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM. |
| PC-49069 |
Dipraglurant
mGlu5 NAM
|
Dipraglurant (ADX-48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor, shows potential for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID). |
| PC-73234 |
Decoglurant
mGluR2/3 NAM
|
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 with antidepressant effect. |
| PC-36001 |
VU6012962
mGlu7 modulator
|
VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM. |
| PC-35962 |
BMS-984923
|
BMS-984923 (BMS-984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling. |
| PC-35879 |
VU0652957
mGlu4 PAM
|
VU0652957 (VU2957, Valiglurax) is a potent, selective mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays. |
| PC-35690 |
VU6001376
mGlu4 PAM
|
VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors. |
| PC-35487 |
VU0418506
mGlu4 PAM
|
VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4). |
| PC-63197 |
VU0424238
|
VU0424238 (Auglurant) is a potent, selective, orally active mGlu5 negative allosteric modulator with Ki of 4.4 nM, displays >900-fold selectivity for mGlu5 versus the other mGlu receptors. |
