| Cat. No. |
Product Name |
Information |
| PC-49747 |
Mavoglurant
mGlu5 NAM
|
AFQ056 (Mavoglurant, AFQ-056) is a potent, subtype-selective and non-competitive inhibitor of mGluR5 with IC50 of 30 nM. |
| PC-49586 |
VU6046980
mGlu7 PAM
|
VU6046980 is a potent, selective and in vivo active mGlu7 positive allosteric modulator (PAM) with EC50 of 0.15 uM (rat mGlu7). |
| PC-49074 |
VU0360172
mGlu5 PAM
|
VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM. |
| PC-49069 |
Dipraglurant
mGlu5 NAM
|
Dipraglurant (ADX-48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor, shows potential for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID). |
| PC-73234 |
Decoglurant
mGluR2/3 NAM
|
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 with antidepressant effect. |
| PC-36001 |
VU6012962
mGlu7 modulator
|
VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM. |
| PC-35962 |
BMS-984923
|
BMS-984923 (BMS-984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling. |
| PC-63197 |
VU0424238
|
VU0424238 (Auglurant) is a potent, selective, orally active mGlu5 negative allosteric modulator with Ki of 4.4 nM, displays >900-fold selectivity for mGlu5 versus the other mGlu receptors. |
| PC-63180 |
AZD8529
|
AZD8529 (AZD-8529) is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
| PC-62984 |
DL-AP4 sodium salt
|
DL-AP4 sodium salt is a broad spectrum glutamate receptor antagonist.. |
| PC-62983 |
LSP4-2022
|
LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays. |
| PC-62957 |
VU0400195
mGluR4 modulator
|
VU0400195 (ML 182) is a potent, selective, brain penetrant and orally active positive allosteric modulator of mGluR4 with EC50 of 291 nM and 376 nM for human and rat mGluR4, respectively. |
