| Cat. No. |
Product Name |
Information |
| PC-60939 |
VU 6001966
mGlu2 modulator
|
VU 6001966 is a potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM. |
| PC-60936 |
VU 0650786
mGlu3 modulator
|
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM). |
| PC-60697 |
mGlu5 PAM 4k
|
mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
| PC-60696 |
JNJ-46778212
|
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM |
| PC-60512 |
Foliglurax
mGluR4 PAM
|
Foliglurax (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60163 |
ADX88178
mGlu4 PAM
|
ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively. |
| PC-60162 |
VU6005649
mGlu7/8 PAM
|
VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively. |
| PC-60149 |
VU6010608
mGlu7 PAM
|
VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM. |
| PC-45900 |
LY-404039
|
A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively. |
| PC-42205 |
VU0364770
mGlu4 PAM
|
VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM. |
| PC-45568 |
LY354740
group 2 mGluR agonist
|
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM. |
| PC-45947 |
LY-341495
Group II mGluR antagonist
|
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively. |
