| Cat. No. |
Product Name |
Information |
| PC-63180 |
AZD8529
mGlu2 PAM
|
AZD8529 (AZD-8529) is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
| PC-62985 |
L-AP4
group III mGluR agonist
|
L-AP4 is a selective group III metabotropic glutamate receptor agonist with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. |
| PC-62984 |
DL-AP4 sodium salt
|
DL-AP4 sodium salt is a broad spectrum glutamate receptor antagonist.. |
| PC-62983 |
LSP4-2022
mGlu4 agonist
|
LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays. |
| PC-62982 |
LSP1-2111
group III mGluR agonist
|
LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively. |
| PC-62958 |
JNJ16567083
mGluR1 antagonist
|
JNJ16567083 (EMQMCM) is a potent and selective mGluR1 antagonist that shows neuroprotective effects in some hypoxia-ischemia models. |
| PC-62957 |
VU0400195
mGluR4 modulator
|
VU0400195 (ML 182) is a potent, selective, brain penetrant and orally active positive allosteric modulator of mGluR4 with EC50 of 291 nM and 376 nM for human and rat mGluR4, respectively. |
| PC-62956 |
VU0410425
rat mGluR1 NAM
|
VU0410425 is a potent, selective negative allosteric modulator of rat mGluR1 with IC50 of 140 nM, inactive at human mGluR1 (IC50>30 uM). |
| PC-62955 |
CDPPB
mGlu5 PAM
|
CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively. |
| PC-62953 |
VU-29
mGlu5 potentiator
|
VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM). |
| PC-62819 |
ZINC12427628
M2 mAChR PAM
|
ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM. |
| PC-62593 |
LY2979165
mGlu2 agonist
|
LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist. |
