| Cat. No. |
Product Name |
Information |
| PC-61059 |
PF470
mGluR5 NAM
|
PF470 is a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM. |
| PC-61058 |
PF-06462894
mGluR5 NAM
|
PF-06462894 is a potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM. |
| PC-60939 |
VU6001966
mGlu2 NAM
|
VU 6001966 is a potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM. |
| PC-60937 |
VU6010572
mGlu3 NAM
|
VU6010572 is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. |
| PC-60936 |
VU 0650786
mGlu3 NAM
|
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM). |
| PC-60822 |
TASP0433864
mGlu2 PAM
|
TASP0433864 is a potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
| PC-60820 |
VU0477573
mGlu5 NAM
|
VU0477573 is a potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca2+ assay IC50 of 32 nM. |
| PC-60818 |
LY2812223
mGlu2 agonist
|
LY2812223 is highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
| PC-60792 |
AZD9272
mGluR5 NAM
|
AZD9272 is a potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM |
| PC-60791 |
AZD2066
mGluR5 antagonist
|
AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively. |
| PC-60731 |
LY3027788
mGlu2/3 antagonist
|
LY3027788 is an orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
| PC-60730 |
LY3020371 hydrochloride
mGlu2/3 antagonist
|
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
