VU0422288 |CAS:1630936-95-6 Probechem Biochemicals

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Chemical Structure : VU0422288

CAS No.: 1630936-95-6

VU0422288 (ML396)

Catalog No.: PC-62129Not For Human Use, Lab Use Only.

VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	360.19
Formula	C17H11Cl2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

References

1. Jalan-Sakrikar N, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37.

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VU0422288 (ML396)

Biological Activity

Physicochemical Properties

References

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