| Cat. No. |
Product Name |
Information |
| PC-35963 |
BMS-952048
mGluR5 modulator
|
BMS-952048 is a positive allosteric modulator of mGluR5 with EC50 of 10 nM. |
| PC-35962 |
BMS-984923
mGluR5 modulator
|
BMS-984923 (BMS 984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling. |
| PC-35879 |
VU0652957
mGlu4 PAM
|
VU0652957 (VU2957, Valiglurax) is a potent, selective mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays. |
| PC-35690 |
VU6001376
mGlu4 PAM
|
VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors. |
| PC-35487 |
VU0418506
mGlu4 PAM
|
VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4). |
| PC-43392 |
MTEP hydrochloride
mGlu5 antagonist
|
MTEP hydrochloride is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM. |
| PC-43360 |
ADX-47273
mGlu5 PAM
|
ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM. |
| PC-63236 |
LY2794193
mGlu3 agonist
|
LY2794193 is a highly potent and selective mGlu3 receptor agonist with Ki of 0.93 nM and EC50 of 47 nM, >100-fold selectivity over mGlu2 receptor. |
| PC-63197 |
VU0424238
mGlu5 NAM
|
Auglurant (VU0424238) is a potent, selective, orally active mGlu5 negative allosteric modulator with Ki of 4.4 nM, displays >900-fold selectivity for mGlu5 versus the other mGlu receptors. |
| PC-43079 |
Methoxy-PEPy
mGlu5 antagonist
|
Methoxy-PEPy is a potent, selective mGlu5 receptor antagonist with IC50 of 1 nM. |
| PC-63181 |
AZD8529 mesylate
mGlu2 PAM
|
AZD8529 mesylate is a potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
| PC-63180 |
AZD8529
mGlu2 PAM
|
AZD8529 (AZD-8529) is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
