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VU6012962

Chemical Structure : VU6012962

CAS No.: 2313526-86-0

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VU6012962 (VU-6012962;VU 6012962)

Catalog No.: PC-36001Not For Human Use, Lab Use Only.

VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM.
VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes and across large ancillary pharmacology panels.
VU6012962 decreases anxiety in the elevated zero maze (EZM) assay in mice.

Physicochemical Properties

M.Wt 448.402
Formula C21H19F3N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide

References

1. Reed CW, et al. J Med Chem. 2019 Jan 4. doi: 10.1021/acs.jmedchem.8b01810.

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