| Cat. No. |
Product Name |
Information |
| PC-27729 |
VU6081679
mGlu8 PAM
|
VU6081679 is a potent, CNS penetrant, orally bioavailable metabotropic glutamate receptor subtype 8 (mGlu8) positive allosteric modulator (PAM) with EC50 of 211/190/162 nM for rat/mouse/human Glu8 receptors respectively. |
| PC-27668 |
VU6024945
mGlu5 NAM
|
VU6024945 is a potent, selective mGlu5 negative allosteric modulator (NAM) with IC50 of 110 nM (hmGlu5). |
| PC-27665 |
GET-73
mGlu5 NAM
|
GET-73 (GET 73, GET73) is a selecrive negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5), reduces alcohol drinking and anxiety-related behaviors. |
| PC-27655 |
Raseglurant
mGlu5 NAM
|
Raseglurant (ADX10059) is a selective metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator (mGlu5 NAM), shows potential for treatment of neuropathic pain and migraine. |
| PC-27118 |
VU6066098
mGlu2 NAM
|
VU6066098 is a potent, selective, and CNS-penetrant mGlu2 negative allosteric modulator (NAM) with IC50 of 77 nM in mGlu2/GIRK assays, with no effect on mGlu3 (IC50>10 uM). |
| PC-26985 |
VU6053371
mGlu3 PAM
|
VU6053371/BI03738809 is a potent, selective, and centrally active metabotropic glutamate receptor subtype 3 (mGlu3) positive allosteric modulator (PAM) with EC50 of 103 nM and 112 nM for human and rat mGlu3. |
| PC-22900 |
VU6023326
mGlu2/mGlu3 PAM
|
VU6023326 (VU326) is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells. |
| PC-22271 |
MMPIP hydrochloride
mGluR7 antagonist
|
MMPIP hydrochloride is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM. |
| PC-22232 |
AZ12216052
mGlu8 PAM
|
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays. |
| PC-22229 |
(S)-3,4-DCPG
mGluR8 agonist
|
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM). |
| PC-21049 |
MK-8768
mGluR2 NAM
|
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8. |
| PC-20615 |
ADX71743
mGluR7 NAM
|
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively. |
