| Cat. No. |
Product Name |
Information |
| PC-60697 |
mGlu5 PAM 4k
mGlu5 PAM
|
mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
| PC-60696 |
JNJ-46778212
mGlu5 PAM
|
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM |
| PC-60513 |
Foliglurax hydrochloride
mGluR4 PAM
|
Foliglurax hydrochloride (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60512 |
Foliglurax
mGluR4 PAM
|
Foliglurax (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60163 |
ADX88178
mGlu4 PAM
|
ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively. |
| PC-60162 |
VU6005649
mGlu7/8 PAM
|
VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively. |
| PC-60149 |
VU6010608
mGlu7 PAM
|
VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM. |
| PC-42137 |
(S)-MCPG
mGluR antagonist
|
(S)-MCPG is the active isomer of (RS)-MCPG, an non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-42138 |
JNJ-16259685
mGluR1 antagonist
|
JNJ-16259685 (JNJ16259685) is a highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM. |
| PC-42124 |
FPTQ
mGluR1 antagonist
|
FPTQ is a potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively. |
| PC-45900 |
LY404039
mGlu2/3 agonist
|
LY404039 is a potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively. |
| PC-42205 |
VU0364770
mGlu4 PAM
|
VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM. |
