| Cat. No. |
Product Name |
Information |
| PC-60818 |
LY2812223
mGlu2 agonist
|
LY2812223 is highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
| PC-60792 |
AZD9272
mGluR5 NAM
|
AZD9272 is a potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM |
| PC-60791 |
AZD2066
mGluR5 antagonist
|
AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively. |
| PC-60731 |
LY3027788
mGlu2/3 antagonist
|
LY3027788 is an orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
| PC-60730 |
LY3020371 hydrochloride
mGlu2/3 antagonist
|
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
| PC-60697 |
mGlu5 PAM 4k
mGlu5 PAM
|
mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
| PC-60696 |
JNJ-46778212
mGlu5 PAM
|
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM |
| PC-60513 |
Foliglurax hydrochloride
mGluR4 PAM
|
Foliglurax hydrochloride (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60512 |
Foliglurax
mGluR4 PAM
|
Foliglurax (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60163 |
ADX88178
mGlu4 PAM
|
ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively. |
| PC-60162 |
VU6005649
mGlu7/8 PAM
|
VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively. |
| PC-60149 |
VU6010608
mGlu7 PAM
|
VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM. |
