| Cat. No. |
Product Name |
Information |
| PC-62130 |
VU0155094
|
VU0155094 is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively. |
| PC-61613 |
Pomaglumetad Methionil
|
Pomaglumetad Methionil (LY2140023 monohydrate) is the methionine amide prodrug of the mGluR2/3 agonist LY-404039 with the potential oral treatment of schizophrenia.. |
| PC-61070 |
BMS-955829
|
A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM). |
| PC-61069 |
BMT-145027
|
A potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM). |
| PC-61060 |
GRN-529
|
A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM. |
| PC-61059 |
PF-470
|
A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM. |
| PC-61058 |
PF-06462894
|
A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM. |
| PC-60937 |
VU 6010572
|
A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. |
| PC-60822 |
TASP 0433864
|
A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
| PC-60820 |
VU0477573
|
A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
| PC-60818 |
LY 2812223
|
A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
| PC-60792 |
AZD 9272
|
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM. |
