VU6005649 |CAS:2137047-43-7 Probechem Biochemicals

Chemical Structure : VU6005649

CAS No.: 2137047-43-7

VU6005649 (VU 6005649;VU-6005649)

Catalog No.: PC-60162Not For Human Use, Lab Use Only.

VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively.
VU6005649 displays no activity for mGlu4 (EC50>10 uM).
VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild type mice.

Physicochemical Properties

M.Wt	357.284
Formula	C16H12F5N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

References

1. Abe M, et al. ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115.

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VU6005649 (VU 6005649;VU-6005649)

Biological Activity

Physicochemical Properties

References

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