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Chemical Structure : JNJ-16259685
CAS No.: 409345-29-5
Catalog No.: PC-42138Not For Human Use, Lab Use Only.
JNJ-16259685 (JNJ16259685) is a highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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JNJ-16259685 (JNJ16259685) is a highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM.
JNJ-16259685 shows no agonist, antagonist or PAM activity toward rat mGlu2/3/4/6 receptors (IC50>10 uM) and does not bind to AMPA, NMDA receptor and other neurotransmitter receptors.
JNJ-16259685 inhibits glutamate-induced Ca2+ mobilization for rat and human mGluR1 with IC50 of 3.24 and 1.21 nM, inhibits glutamate-mediated inositol phosphate production with IC50 of 1.73 nM.
JNJ-16259685 attenuates drug context-induced reinstatement of cocaine seeking in rats.
| M.Wt | 325.4015 | |
| Formula | C20H23NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)- |
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1. Lavreysen H, et al. Neuropharmacology. 2004 Dec;47(7):961-72.
2. Mabire D, et al. J Med Chem. 2005 Mar 24;48(6):2134-53.
3. Xie X, et al. Psychopharmacology (Berl). 2010 Jan;208(1):1-11.
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