Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Foliglurax hydrochloride
Catalog No.: PC-60513Not For Human Use, Lab Use Only.
Foliglurax hydrochloride (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Foliglurax hydrochloride (PXT002331) is a potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
Foliglurax shows more than 15-, 110- and 50-times higher selectivity for mGluR4 than for mGluR6, -7, and -8, respectively, no effect on NMDA, AMPA, kainate, group I or group II mGluRs, COMT, MAO-A or MAO-B (IC50>10 uM).
Foliglurax demonstrates significant antiparkinsonian activity in rodent models of PD motor symptoms.
| M.Wt | 457.973 | |
| Formula | C23H24ClN3O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Charvin D, et al. J Med Chem. 2017 Oct 26;60(20):8515-8537.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
