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VU0364770

Chemical Structure : VU0364770

CAS No.: 61350-00-3

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VU0364770 (VU-0364770, VU 0364770)

Catalog No.: PC-42205Not For Human Use, Lab Use Only.

VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM.

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25 mg $128 In stock
50 mg $198 In stock
100 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM.
VU0364770 does not significantly bind to a panel of 68 GPCRs, ion channels and transporters.
VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

Physicochemical Properties

M.Wt 232.6657
Formula C12H9ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyridinecarboxamide, N-(3-chlorophenyl)-

References

1. Jones CK, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

2. Iderberg H, et al. Neuropharmacology. 2015 Aug;95:121-9.

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