| Cat. No. |
Product Name |
Information |
| PC-27656 |
Raseglurant hydrochloride
mGlu5 NAM
|
Raseglurant hydrochloride (ADX10059) is a selective metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator (mGlu5 NAM), shows potential for treatment of neuropathic pain and migraine. |
| PC-27180 |
JNJ-46356479
mGlu2 PAM
|
JNJ-46356479 is a potent and selective, orally bioavailable mGlu2 positive allosteric modulator (PAM) with EC50 of 78 nM and Emax=256%. |
| PC-27166 |
(S)-3,5-dihydroxyphenylglycine
mGluR1/mGluR5 agonist
|
(S)-3,5-DHPG ((S)-3,5-dihydroxyphenylglycine) is a selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively, exhibits anxiolytic activity. |
| PC-27165 |
DHPG
mGluR1/mGluR5 agonist
|
DHPG (3,5-dihydroxyphenylglycine) is a selective agonist of group I metabotropic glutamate receptor mGluR1/5 with EC50 of 60 nM for mGluR1, activates the phospholipase C (PLC) pathway and protein kinase C (PKC). |
| PC-27119 |
VU6001192
mGlu2 NAM
|
VU6001192 is a potent and highly selective mGlu2 negative allosteric modulator (NAM) with IC50 of 207 nM in calcium mobilization mGlu2 assays, is inactive against mGlu3 up to 30 uM |
| PC-26043 |
Fenobam
mGluR5 antagonist
|
Fenobam is a potent, selective, BBB-penetrant and orally active mGluR5 antagonist with IC50 of 84 nM. |
| PC-26042 |
Basimglurant
mGluR5 NAM
|
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 receptor (mGluR5) negative allosteric modulator (NAM) with Kd of 1.1 nM. |
| PC-26041 |
MTEP
mGluR5 antagonist
|
MTEP is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM. |
| PC-26040 |
MPEP hydrochloride
mGluR5 antagonist
|
MPEP hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor (mGluR5) antagonist with IC50 of 36 nM, has anxiolytic-or antidepressant-like effects. |
| PC-26039 |
MPEP
mGluR5 antagonist
|
MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor (mGluR5) antagonist with IC50 of 36 nM, has anxiolytic-or antidepressant-like effects. |
| PC-26037 |
VU6035386
mGluR5 NAM
|
VU6035386 is a potent, selective negative allosteric modulator (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5, mGluR5) with IC50 of 64 nM. |
| PC-24064 |
VU6033685
mGlu1 PAM
|
VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%. |
