| Cat. No. |
Product Name |
Information |
| PC-26037 |
VU6035386
mGluR5 NAM
|
VU6035386 is a potent, selective negative allosteric modulator (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5, mGluR5) with IC50 of 64 nM. |
| PC-24064 |
VU6033685
mGlu1 PAM
|
VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%. |
| PC-23781 |
VU6004909
mGlu1 PAM
|
VU6004909 is a selective, CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 25.7 nM and 31 nM for human and rat mGlu1 respectively. |
| PC-23780 |
LY367385
mGluR1 antagonist
|
LY367385 is a potent, highly selective mGluR1 antagonis with IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, shows no activity against mGluR5. |
| PC-23779 |
VU0486321
mGlu1 PAM
|
VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4. |
| PC-23778 |
VU0483605
mGlu1 PAM
|
VU0483605 is a potent, selective positive allosteric modulator (PAM) of mGluR1 with EC50 of 350 nM. |
| PC-23777 |
VU6024578
mGlu1 PAM
|
VU6024578 (BI02982816) is a selective and CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 54 nM and 46 nM for human and rat mGlu1 respectively. |
| PC-22952 |
FO-4-15
mGluR1 activator
|
FO-4-15 is a small molecule taregting mGluR1 with low cytotoxicity and anti-H2O2 effect, significantly reduces Aβ accumulation, Tau hyper-phosphorylation, and synaptic impairments in 3×Tg mice, activates mGluR1/CaMKIIα pathway. |
| PC-22950 |
LBG20304
GluK5 ligand
|
LBG20304 is a potent, selective ligand for homomeric GluK5 receptor with IC50 of 432 nM, >40-fold selective over GluK1-3 and >100-fold selectivity over native AMPA and NMDA receptors. |
| PC-22907 |
VU0092273
mGlu5 PAM
|
VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) with an EC50 of 0.27 uM, binds to the MPEP site. |
| PC-22906 |
VU0463597
mGlu3 NAM
|
ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 with IC50 of 0.66 uM, shows >15-fold selectivity over mGlu2 and is inactive against mGlu5. |
| PC-22905 |
ML337
mGlu3 NAM
|
ML337 is a potent, selective and brain-penetrant negative allosteric modulator of mGlu3 with IC50 of 593 nM, with no effect on mGlu2 (IC50>30 uM). |
