Chemical Structure : ADX71743
CAS No.:
1431641-29-0
ADX71743
(ADX 71743)
Catalog No.: PC-20615Not For Human Use, Lab Use Only.
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively.
ADX71743 induced a concentration-dependent rightward shift of the L-AP4 concentration-response curve without any impact on maximal efficacy of the agonist. no detectable activity (agonist or allosteric effects) in cell lines expressing hmGlu3, hmGlu4, rmGlu5, hmGlu6, and hmGlu8.
ADX71743 (50, 100, 150 mg/kg, s.c.) caused no impairment of locomotor activity in rats and mice or activity on rotarod in mice.
ADX71743 had an anxiolytic-like profile in the marble burying and elevated plus maze tests, dose-dependently reducing the number of buried marbles and increasing open arm exploration, respectively.
Physicochemical Properties
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M.Wt
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269.34
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Formula
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C17H19NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C1CC(C2=CC=C(C)C=C2C)CC3=C1N=C(CC)O3
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References
1. Kalinichev M, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
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