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Chemical Structure : MK-8768
Catalog No.: PC-21049Not For Human Use, Lab Use Only.
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8.
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MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8.
MK-8768 demonstrates an excellent overall selectivity profile with weak to no activity on the hERG, IKs, and Nav1.5 ion channels and no confirmed activities < 10 μM in a Panlabs screen of >120 off-targets.
MK-8768 exhibits good oral pharmacokinetics and demonstrated efficacy in a rhesus monkey model of executive function and attention.
| M.Wt | 433.44 | |
| Formula | C21H22F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michael T Rudd, et al. ACS Med Chem Lett. 2023 Jul 12;14(8):1088-1094.
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