| Cat. No. |
Product Name |
Information |
| PC-22271 |
MMPIP hydrochloride
mGlu7 NAM
|
MMPIP hydrochloride is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM. |
| PC-22270 |
XAP044
mGlu7 antagonist
|
XAP044 is a potent, selective antagonist of metabotropic glutamate receptor subtype 7 (mGlu7), inhibits lateral amygdala long term potentiation (LTP) in brain slices with IC50 of 88 nM. |
| PC-22231 |
VU0361737
mGluR4 PAM
|
VU0361737 (ML128) is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. |
| PC-22230 |
VU0155041
mGluR4 PAM
|
VU0155041 is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 798 and 693 nM at human and rat mGluR4, respectively. |
| PC-22229 |
(S)-3,4-DCPG
mGluR8 agonist
|
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM). |
| PC-21049 |
MK-8768
mGluR2 modulator
|
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8. |
| PC-20615 |
ADX71743
mGluR7 modulator
|
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively. |
| PC-20614 |
CVN636
mGluR7 agonist
|
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively. |
| PC-20314 |
JNJ-42491293
mGlu2 ago-PAM
|
JNJ-42491293 (JNJ 42491293) is a potent, mGlu2-selective allosteric agonist and positive allosteric modulator (ago-PAM). |
| PC-49746 |
HTL14242
mGlu5 NAM
|
HTL14242 (HTL0014242) a potent, selective mGlu5 negative allosteric modulator (NAM) with pKi of 9.3 and pIC50 of 9.2, shows high selectivity within the metabotropic family of GPCRs. |
| PC-49593 |
VU6027459
mGlu7 PAM
|
VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7). |
| PC-38454 |
ML254
mGlu5 PAM
|
ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM. |
