| Cat. No. |
Product Name |
Information |
| PC-62956 |
VU0410425
rat mGluR1 NAM
|
VU0410425 is a potent, selective negative allosteric modulator of rat mGluR1 with IC50 of 140 nM, inactive at human mGluR1 (IC50>30 uM). |
| PC-62955 |
CDPPB
mGlu5 PAM
|
CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively. |
| PC-62953 |
VU-29
mGlu5 potentiator
|
VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM). |
| PC-62819 |
ZINC12427628
M2 mAChR PAM
|
ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM. |
| PC-62593 |
LY2979165
mGlu2 agonist
|
LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist. |
| PC-62130 |
VU0155094
group III mGluR PAM
|
VU0155094 (ML397) is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively. |
| PC-62129 |
VU0422288
Group III mGluR modulator
|
VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6). |
| PC-62120 |
ML353
mGlu5 modulator
|
ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity. |
| PC-61613 |
Pomaglumetad Methionil
mGlu2/3 agonist
|
Pomaglumetad Methionil (LY2140023 monohydrate) is the methionine amide prodrug of the mGluR2/3 agonist LY-404039 with the potential oral treatment of schizophrenia. |
| PC-61612 |
LY-487379 hydrochloride
|
LY-487379 hydrochloride is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61611 |
LY487379
mGlu2 PAM
|
LY487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61513 |
JNJ-40411813
mGlu2 PAM
|
JNJ-40411813 (ADX71149) is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM. |
