| Cat. No. |
Product Name |
Information |
| PC-62130 |
VU0155094
group III mGluR PAM
|
VU0155094 (ML397) is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively. |
| PC-62129 |
VU0422288
Group III mGluR modulator
|
VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6). |
| PC-62120 |
ML353
mGlu5 modulator
|
ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity. |
| PC-61613 |
Pomaglumetad Methionil
mGlu2/3 agonist
|
Pomaglumetad Methionil (LY2140023 monohydrate) is the methionine amide prodrug of the mGluR2/3 agonist LY-404039 with the potential oral treatment of schizophrenia. |
| PC-61612 |
LY-487379 hydrochloride
|
LY-487379 hydrochloride is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61611 |
LY487379
mGlu2 PAM
|
LY487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61513 |
JNJ-40411813
mGlu2 PAM
|
JNJ-40411813 (ADX71149) is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM. |
| PC-61212 |
AMN 082 dihydrochloride
mGluR7 agonist
|
AMN 082 dihydrochloride (AMN082) is potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM. |
| PC-61211 |
AMN 082
mGluR7 agonist
|
AMN 082 (AMN082) is a potent, selective mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM. |
| PC-61070 |
BMS-955829
mGluR5 PAM
|
BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM). |
| PC-61069 |
BMT-145027
mGluR5 PAM
|
BMT-145027 is a potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM). |
| PC-61060 |
GRN-529
mGluR5 NAM
|
GRN-529 is a highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM. |
