Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AMN 082
CAS No.: 83027-13-8
Catalog No.: PC-61211Not For Human Use, Lab Use Only.
AMN 082 (AMN082) is a potent, selective mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AMN 082 (AMN082) is a potent, selective mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM.
AMN 082 displays no activating or inhibitory effects at other mGluR subtypes and ionotropic GluRs.
AMN 082 potently inhibits cAMP accumulation and stimulates GTPgammaS binding with EC50 of 64-290 nM.
AMN 082 elevates the plasma stress hormones corticosterone and corticotropin in an mGluR7-dependent fashion in vivo.
| M.Wt | 392.546 | |
| Formula | C28H28N2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N,N'-Bis(diphenylmethyl)-1,2-ethanediamine |
|
1. Mitsukawa K, et al. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7.
2. Pelkey KA, et al. Neuropharmacology. 2007 Jan;52(1):108-17.
3. Suzuki G, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):147-56.
4. Fendt M, et al. Mol Psychiatry. 2008 Oct;13(10):970-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
