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BMS-955829

Chemical Structure : BMS-955829

CAS No.: 1375751-08-8

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BMS-955829 (BMS 955829, BMS955829)

Catalog No.: PC-61070Not For Human Use, Lab Use Only.

BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).
    BMS-955829  displays no any measurable PAM, NAM or agonist activity at other mGluRs (>10 uM).
    BMS-955829  reverses MK-801 induced deficits in executive function in rats, demonstrates robust in vivo efficacy in preclinical models of schizophrenia.

    Physicochemical Properties

    M.Wt 376.363
    Formula C22H14F2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one

    References

    1. Yang F, et al. ACS Med Chem Lett. 2016 Jan 4;7(3):289-93.

    2. Narang AS, et al. Eur J Pharm Biopharm. 2017 Aug;117:333-345.

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