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Chemical Structure : BMS-955829
Catalog No.: PC-61070Not For Human Use, Lab Use Only.
BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).
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BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).
BMS-955829 displays no any measurable PAM, NAM or agonist activity at other mGluRs (>10 uM).
BMS-955829 reverses MK-801 induced deficits in executive function in rats, demonstrates robust in vivo efficacy in preclinical models of schizophrenia.
| M.Wt | 376.363 | |
| Formula | C22H14F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang F, et al. ACS Med Chem Lett. 2016 Jan 4;7(3):289-93.
2. Narang AS, et al. Eur J Pharm Biopharm. 2017 Aug;117:333-345.
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