LY-487379 hydrochloride |CAS:353229-59-1 Probechem Biochemicals

Chemical Structure : LY-487379 hydrochloride

CAS No.: 353229-59-1

LY-487379 hydrochloride (LY487379 hydrochloride)

Catalog No.: PC-61612Not For Human Use, Lab Use Only.

LY-487379 hydrochloride is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3.

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100 mg	$598	In stock
200 mg	$898	In stock
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Biological Activity

LY-487379 hydrochloride is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3.
LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2.
LY-487379 potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus.

Physicochemical Properties

M.Wt	488.91
Formula	C21H19F3N2O4S.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride

References

1. Johnson MP, et al. J Med Chem. 2003 Jul 17;46(15):3189-92.

2. Schaffhauser H, et al. Mol Pharmacol. 2003 Oct;64(4):798-810.

3. Poisik O, et al. Neuropharmacology. 2005;49 Suppl 1:57-69.

LY-487379 hydrochloride (LY487379 hydrochloride)

Biological Activity

Physicochemical Properties

References

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