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Chemical Structure : ML353
CAS No.: 2990506-75-5
Catalog No.: PC-62120Not For Human Use, Lab Use Only.
ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.
ML353 (VU0478006) displays >200-fold selectivity over mGlu1, 2-4, 6-8, and >20-fold improvement over the prior mGlu5 SAM tool compound 5MPEP.
| M.Wt | 306.34 | |
| Formula | C19H15FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-azabicyclo[3.1.0]hexan-3-yl(5-((3-fluorophenyl)ethynyl)pyridin-2-yl)methanone |
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1. Gregory KJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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