ML353 (VU0478006) | mGlu5 modulator | Probechem Biochemicals

Chemical Structure : ML353

CAS No.: 2990506-75-5

ML353 (VU0478006, ML353, VU 0478006)

Catalog No.: PC-62120Not For Human Use, Lab Use Only.

ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Biological Activity

ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.
ML353 (VU0478006) displays >200-fold selectivity over mGlu1, 2-4, 6-8, and >20-fold improvement over the prior mGlu5 SAM tool compound 5MPEP.

Physicochemical Properties

M.Wt	306.34
Formula	C19H15FN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-azabicyclo[3.1.0]hexan-3-yl(5-((3-fluorophenyl)ethynyl)pyridin-2-yl)methanone

References

1. Gregory KJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML353 (VU0478006, ML353, VU 0478006)

Biological Activity

Physicochemical Properties

References

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