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Chemical Structure : BMT-145027
CAS No.: 2018282-44-3
Catalog No.: PC-61069Not For Human Use, Lab Use Only.
BMT-145027 is a potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
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BMT-145027 is a potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM).
BMT-145027 does not engage the receptor at the MPEP and CPPHA allosteric sites.
BMT-145027 improves cognition in a preclinical rodent model of learning and memory.
| M.Wt | 438.838 | |
| Formula | C23H14ClF3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(4-chloro-3-(trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile |
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1. Hill MD, et al. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.
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