| Cat. No. |
Product Name |
Information |
| PC-22905 |
ML337
mGlu3 NAM
|
ML337 is a potent, selective and brain-penetrant negative allosteric modulator of mGlu3 with IC50 of 593 nM, with no effect on mGlu2 (IC50>30 uM). |
| PC-22901 |
VU6020933
mGlu2/mGlu3 PAM
|
VU6020933 is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 164/476 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells. |
| PC-22900 |
VU6023326
mGlu2/mGlu3 PAM
|
VU6023326 is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells. |
| PC-22899 |
LY379268
mGlu2/3 agonist
|
LY379268 is a potent, selective group II metabotropic glutamate (mGlu) receptor agonist with Ki of 40.6 nM and 4.7 nM, EC50 of 3.91 nM and 7.63 nM for mGlu2 and mGlu3, respectively. |
| PC-22270 |
XAP044
mGlu7 antagonist
|
XAP044 is a potent, selective antagonist of metabotropic glutamate receptor subtype 7 (mGlu7), inhibits lateral amygdala long term potentiation (LTP) in brain slices with IC50 of 88 nM. |
| PC-22231 |
VU0361737
mGluR4 PAM
|
VU0361737 (ML128) is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. |
| PC-22230 |
VU0155041
mGluR4 PAM
|
VU0155041 is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 798 and 693 nM at human and rat mGluR4, respectively. |
| PC-22229 |
(S)-3,4-DCPG
mGluR8 agonist
|
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM). |
| PC-21049 |
MK-8768
mGluR2 modulator
|
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8. |
| PC-20615 |
ADX71743
mGluR7 modulator
|
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively. |
| PC-20614 |
CVN636
mGluR7 agonist
|
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively. |
| PC-49746 |
HTL14242
mGlu5 NAM
|
HTL14242 (HTL0014242) a potent, selective mGlu5 negative allosteric modulator (NAM) with pKi of 9.3 and pIC50 of 9.2, shows high selectivity within the metabotropic family of GPCRs. |
