VU0463597 | mGlu3 NAM | Probechem Biochemicals

Chemical Structure : VU0463597

CAS No.: 1382481-79-9

VU0463597 (ML289)

Catalog No.: PC-22906Not For Human Use, Lab Use Only.

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 with IC50 of 0.66 uM, shows >15-fold selectivity over mGlu2 and is inactive against mGlu5.

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10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$328	In stock
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Biological Activity

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 with IC50 of 0.66 uM, shows >15-fold selectivity over mGlu2 and is inactive against mGlu5.

Physicochemical Properties

M.Wt	349.43
Formula	C22H23NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone

References

1. Douglas J Sheffler, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5.

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VU0463597 (ML289)

Biological Activity

Physicochemical Properties

References

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