VU0483605

Chemical Structure : VU0483605

CAS No.: 1623101-11-0

Catalog No.: PC-23778Not For Human Use, Lab Use Only.

VU0483605 is a potent, selective positive allosteric modulator (PAM) of mGluR1 with EC50 of 350 nM.

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Biological Activity

VU0483605 is a potent, selective positive allosteric modulator (PAM) of mGluR1 with EC50 of 350 nM.

M.Wt	446.67
Formula	C20H10Cl3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide

1. Cavallo D, et al. Neuropharmacology. 2020 Jan 1;162:107810.

2. Cho HP, et al. ACS Chem Biol. 2014 Oct 17;9(10):2334-46.