VU6023326 (VU326)

Chemical Structure : VU6023326

Catalog No.: PC-22900Not For Human Use, Lab Use Only.

VU6023326 (VU326) is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells.

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Biological Activity

VU6023326 (VU326) is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells.

Physicochemical Properties

M.Wt	444.52
Formula	C25H32O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(3-(4-(3,3-dimethylbutanoyl)-3-hydroxy-2-methylphenoxy)-2-methylpropoxy)-4-methoxybenzoic acid

References

1. Yousuke Yamada, et al. Bioorg Med Chem Lett. 2021 Oct 15:50:128342.

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VU6023326 (VU326)

Biological Activity

Physicochemical Properties

References

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