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VU0486321

Chemical Structure : VU0486321

CAS No.: 1816301-67-3

VU0486321

Catalog No.: PC-23779Not For Human Use, Lab Use Only.

VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4.

Physicochemical Properties

M.Wt 398.77
Formula C20H12ClFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Furancarboxamide, N-[3-chloro-4-(4-fluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-3-methyl-

References

1. Garcia-Barrantes PM, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5107-10.

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