Chemical Structure : LBG20304
CAS No.:
LBG20304
(LBG 20304)
Catalog No.: PC-22950Not For Human Use, Lab Use Only.
LBG20304 is a potent, selective ligand for homomeric GluK5 receptor with IC50 of 432 nM, >40-fold selective over GluK1-3 and >100-fold selectivity over native AMPA and NMDA receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LBG20304 is a potent, selective ligand for homomeric GluK5 receptor with IC50 of 432 nM, >40-fold selective over GluK1-3 and >100-fold selectivity over native AMPA and NMDA receptors.
LBG20304 interacts with the GluK5 orthosteric binding pocket.
LBG20304 (10 uM) does not activate the GluK2/5 receptor complex, does not antagonize these receptors after activation by Glu.
LBG20304 (10 and 100 μM) is a weak agonist in native murine receptors in hippocampal neurons known to express heteromeric GluK2/5 receptors.
Physicochemical Properties
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M.Wt
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382.38
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Formula
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C19H18N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,3R,4R)-3-(Carboxymethyl)-4-(5-(6-hydroxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylic Acid
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References
1. Buschbom-Helmke S, et al. J Med Chem. 2024 Aug 12. doi: 10.1021/acs.jmedchem.4c01311.
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