| Cat. No. |
Product Name |
Information |
| PC-42136 |
DFMTI
mGluR1 antagonist
|
DFMTI (MK5435) is a potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
| PC-42134 |
CFMTI
mGluR1 antagonist
|
CFMTI is a potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively. |
| PC-45423 |
JNJ-42153605
mGlu2 PAM
|
JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM. |
| PC-42135 |
Ro 67-7476
p-ERK1/2 agonist, rat mGlu1R PAM
|
Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents. |
| PC-42140 |
PHCCC
mGluR4 PAM
|
PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors. |
| PC-45568 |
LY354740
group 2 mGluR agonist
|
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM. |
| PC-45947 |
LY-341495
Group II mGluR antagonist
|
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively. |
| PC-42118 |
(RS)-MCPG
mGluR antagonist
|
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-42119 |
E4CPG
mGluR antagonist
|
E4CPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-45635 |
Trans-ACPD
mGluR agonist
|
Trans-ACPD is a equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD, selective agonist for metabotropic glutamate receptors. |
| PC-24064 |
VU6033685
mGlu1 PAM
|
VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%. |
| PC-23781 |
VU6004909
mGlu1 PAM
|
VU6004909 is a selective, CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 25.7 nM and 31 nM for human and rat mGlu1 respectively. |
