| Cat. No. |
Product Name |
Information |
| PC-42136 |
DFMTI
mGluR1 antagonist
|
DFMTI (MK5435) is a potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
| PC-42134 |
CFMTI
mGluR1 antagonist
|
CFMTI is a potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively. |
| PC-45423 |
JNJ-42153605
mGlu2 PAM
|
JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM. |
| PC-42135 |
Ro 67-7476
p-ERK1/2 agonist, rat mGlu1R PAM
|
Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents. |
| PC-42140 |
PHCCC
mGluR4 PAM
|
PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors. |
| PC-45568 |
LY354740
group 2 mGluR agonist
|
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM. |
| PC-45947 |
LY-341495
Group II mGluR antagonist
|
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively. |
| PC-42118 |
(RS)-MCPG
mGluR antagonist
|
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-42119 |
E4CPG
mGluR antagonist
|
E4CPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-45635 |
Trans-ACPD
mGluR agonist
|
Trans-ACPD is a equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD, selective agonist for metabotropic glutamate receptors. |
| PC-22952 |
FO-4-15
mGluR1 activator
|
FO-4-15 is a small molecule taregting mGluR1 with low cytotoxicity and anti-H2O2 effect, significantly reduces Aβ accumulation, Tau hyper-phosphorylation, and synaptic impairments in 3×Tg mice, activates mGluR1/CaMKIIα pathway. |
| PC-22950 |
LBG20304
GluK5 ligand
|
LBG20304 is a potent, selective ligand for homomeric GluK5 receptor with IC50 of 432 nM, >40-fold selective over GluK1-3 and >100-fold selectivity over native AMPA and NMDA receptors. |
