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CFMTI

Chemical Structure : CFMTI

CAS No.: 864864-17-5

CFMTI (mGluR1 antagonist)

Catalog No.: PC-42134Not For Human Use, Lab Use Only.

CFMTI is a potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CFMTI is a potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively.
CFMTI displays >2,000-fold selectivity over mGluR5, and no actvity for other mGluR subtypes.
CFMTI reduces methamphetamine-induced hyperlocomotion and MK-801-induced social withdrawal without any cataleptogenic activities in mice.

Physicochemical Properties

M.Wt 349.3616
Formula C19H16FN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.2 mg/mL (Need warming)

Chemical Name/SMILES

1H-Isoindol-1-one, 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-

References

1. Satow A, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90.

2. Hikichi H, et al. Eur J Pharmacol. 2010 Aug 10;639(1-3):99-105.

3. Suzuki G, et al. Neuroscience. 2010 Jul 14;168(3):787-96.

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