PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors.
PHCCC potentiates the response to glutamate (2 uM) 5.6-fold compared with glutamate alone in FLIPR assay.
PHCCC shows significant, dose-dependent anticonflict effects without affecting the threshold current or water intake in rats.
PHCCC also reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors in rats.
