Chemical Structure : JNJ-42153605
CAS No.: 1254977-87-1
Catalog No.: PC-45423Not For Human Use, Lab Use Only.
JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $158 | In stock | |
25 mg | $258 | In stock | |
50 mg | $428 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM.
JNJ-42153605 displays >100-fold selectivity over mGlu1,3-8 receptors.
JNJ-42153605 shows a central in vivo efficacy by inhibition of REM sleep state (3 mg/kg, po) in the rat sleep–wake EEG paradigm; reverses PCP-induced hyperlocomotion ( ED50 of 5.4 mg/kg, sc).
M.Wt | 400.44 | |
Formula | C22H23F3N4 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
DMSO: 10 mM |
|
Chemical Name/SMILES |
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)- |
1. Cid JM, et al. J Med Chem. 2012 Oct 25;55(20):8770-89.
2. Wyckhuys T, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):375-86.
3. Megens AA, et al. Eur J Pharmacol. 2014 Mar 15;727:130-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright