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Chemical Structure : DFMTI
CAS No.: 864864-86-8
Catalog No.: PC-42136Not For Human Use, Lab Use Only.
DFMTI (MK5435) is a potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DFMTI (MK5435) is a potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively.
DFMTI displasy liitle to no activity for mGluR5, mGluR2 and mGluR8.
DFMTI has improved in vivo DMPK profiles and shows antipsychotic-like effect at a dose of 1 mg/kg in an animal model.
| M.Wt | 368.3799 | |
| Formula | C20H18F2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Isoindol-1-one, 5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-2-(1-methylethyl)- |
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1. Ito S, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5310-3.
2. Cho HP, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.
3. Satoh A, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5464-8.
4. Hostetler E, et al. Synapse. 2011 Feb;65(2):125-35.
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