Catalog No.: PC-42135Not For Human Use, Lab Use Only.
Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents.
Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents.
Ro 67-7476 also is a potent p-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate
Ro 67-7476 has no activity for mGluR5 at 1 uM and Adrenergic α1, α2, β1, β2 and GABAA at 10 uM.
Ro 67-7476 has no effect on the glutamate-induced currents in human mGlu1a receptor-expressing cells.
