VU6033685 | mGlu1 PAM | Probechem Biochemicals

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Chemical Structure : VU6033685

VU6033685 (BI1752, BI-1752)

Catalog No.: PC-24064Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%.
VU6033685 displays no activity against mGlu2/3/4, and mGlu6/6/8 receptors (Ec50>10 uM).
VU6033685 (1-10 mg/kg, p.o.) reverses amphetamine-induced hyperlocomotion (AHL) in rats.
VU6033685 (1-30 mg/kg) reverses MK-801-induced disruption of novel object recognition in rats.

Physicochemical Properties

M.Wt	366.85
Formula	C20H19ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-((6-cyclopropyl-2-methylpyridin-3-yl)methyl)-5-(1H-pyrazol-1-yl)benzamide

References

1. Reed CW, et al. ACS Chem Neurosci. 2025 Feb 5. doi: 10.1021/acschemneuro.5c00014.

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VU6033685 (BI1752, BI-1752)

Biological Activity

Physicochemical Properties

References

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