VU0155094 | group III mGluR PAM | Probechem Biochemicals

Chemical Structure : VU0155094

VU0155094 (ML397)

Catalog No.: PC-62130Not For Human Use, Lab Use Only.

VU0155094 (ML397) is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively.

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Biological Activity

VU0155094 (ML397) is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively.
VU0155094 displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6).

Physicochemical Properties

M.Wt	436.526
Formula	C24H24N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 4-[3-[2-(4-acetamidophenyl)sulfanylacetyl]-2,5-dimethylpyrrol-1-yl]benzoate

References

1. Jalan-Sakrikar N, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37.

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VU0155094 (ML397)

Biological Activity

Physicochemical Properties

References

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