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ADX88178

Chemical Structure : ADX88178

CAS No.: 1235318-89-4

ADX88178 (ADX 88178, ADX-88178)

Catalog No.: PC-60163Not For Human Use, Lab Use Only.

ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.

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Biological Activity

ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.
ADX88178 displays highly selective for mGluR4 with minimal activities at other mGluRs.
ADX88178 reverses haloperidol-induced catalepsy, improves movement in rodent models of Parkinson's disease.

Physicochemical Properties

M.Wt 272.33
Formula C12H12N6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

References

1. Le Poul E, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):167-77.

2. Kalinichev M, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.

3. Volpi C, et al. Neuropharmacology. 2016 Mar;102:59-71.

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