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Chemical Structure : ADX88178
CAS No.: 1235318-89-4
Catalog No.: PC-60163Not For Human Use, Lab Use Only.
ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.
ADX88178 displays highly selective for mGluR4 with minimal activities at other mGluRs.
ADX88178 reverses haloperidol-induced catalepsy, improves movement in rodent models of Parkinson's disease.
| M.Wt | 272.33 | |
| Formula | C12H12N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine |
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1. Le Poul E, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):167-77.
2. Kalinichev M, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.
3. Volpi C, et al. Neuropharmacology. 2016 Mar;102:59-71.
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