Catalog No.: PC-60696Not For Human Use, Lab Use Only.
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM.
JNJ-46778212 potentiates DHPG-induced long-term depression and induces calcium mobilization and ERK phosphorylation, does not potentiate mGlu5 modulation of NMDA receptor currents nor NMDA receptor-dependent long-term potentiation.
JNJ-46778212 demonstrates in vivo efficacy in multiple preclinical models of schizophrenia, coupled with good DMPK profile and acceptable therapeutic window.
