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Chemical Structure : mGlu5 PAM 4k
Catalog No.: PC-60697Not For Human Use, Lab Use Only.
mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM.
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mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM.
mGlu5 PAM 4k displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8.
mGlu5 PAM 4k shows antipsychotic-like activity in vivo and for treatment of schizophrenia.
| M.Wt | 338.342 | |
| Formula | C18H15FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434.
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