Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-mGluR-mGlu5 PAM 4k
mGlu5 PAM 4k

Chemical Structure : mGlu5 PAM 4k

CAS No.: 1382782-16-2

Add to Favorites

mGlu5 PAM 4k

Catalog No.: PC-60697Not For Human Use, Lab Use Only.

mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM.
    mGlu5 PAM 4k displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8.
    mGlu5 PAM 4k shows antipsychotic-like activity in vivo and for treatment of schizophrenia.

    Physicochemical Properties

    M.Wt 338.342
    Formula C18H15FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(5-fluoropyridin-2-yl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

    References

    1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: