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MMPIP

Chemical Structure : MMPIP

CAS No.: 479077-02-6

MMPIP

Catalog No.: PC-27730Not For Human Use, Lab Use Only.

MMPIP is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MMPIP is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM.
MMPIP hydrochloride reversed antidepressant-like effects of AMN082 in rats.
MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.

Physicochemical Properties

M.Wt 333.35
Formula C19H15N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(4-Methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxazolo[4,5-c]pyridin-4(5H)-one

References

1. Kotlinska JH, et al. Eur J Pharmacol. 2019 Sep 5;858:172512.

2. Palazzo E, et al. Pain. 2015 Jun;156(6):1060-1073.

3. Pałucha-Poniewiera A, et al. Behav Brain Res. 2013 Feb 1;238:109-12.

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