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Dipraglurant

Chemical Structure : Dipraglurant

CAS No.: 872363-17-2

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Dipraglurant (ADX48621, ADX 48621)

Catalog No.: PC-49069Not For Human Use, Lab Use Only.

Dipraglurant (ADX48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor with IC50 of 21 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dipraglurant (ADX48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor with IC50 of 21 nM.
Dipraglurant (ADX48621) shows potential for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).

Physicochemical Properties

M.Wt 265.291
Formula C16H12FN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine

References

1. Sciamanna G, et al. Neuropharmacology. 2014 Oct;85:440-50.

2. Pourmirbabaei S, et al. Eur J Pharmacol. 2019 Jul 15;855:149-159.

3. Bezard E, et al. Mov Disord. 2014 Jul;29(8):1074-9.

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