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VU0360172

Chemical Structure : VU0360172

CAS No.: 1310012-12-4

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VU0360172 (VU 0360172)

Catalog No.: PC-49074Not For Human Use, Lab Use Only.

VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.
VU0360172 displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors.
VU0360172 exhibits antipsychotic-like activity in a rodent model, also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Physicochemical Properties

M.Wt 294.329
Formula C18H15FN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide

References

1. Celli R, et al. Neuropharmacology. 2020 Nov 1;178:108240.

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