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Chemical Structure : VU0418506
Catalog No.: PC-35487Not For Human Use, Lab Use Only.
VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).
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VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).
VU0418506 displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8.
VU0418506 does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9.
| M.Wt | 262.67 | |
| Formula | C12H8ClFN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Engers DW, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200.
2. Niswender CM, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11.
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