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VU0418506

Chemical Structure : VU0418506

CAS No.: 1330624-42-4

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VU0418506 (VU 0418506)

Catalog No.: PC-35487Not For Human Use, Lab Use Only.

VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).
    VU0418506 displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8.
    VU0418506 does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9.

    Physicochemical Properties

    M.Wt 262.67
    Formula C12H8ClFN4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine

    References

    1. Engers DW, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200.

    2. Niswender CM, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11.

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