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Chemical Structure : VU6001376
Catalog No.: PC-35690Not For Human Use, Lab Use Only.
VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors.
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VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors.
VU6001376 demonstrates efficacy in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson's disease.
| M.Wt | 400.408 | |
| Formula | C18H14F2N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bollinger S, et al. J Med Chem. 2018 Sep 24. doi: 10.1021/acs.jmedchem.8b00994.
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